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KMID : 0363119920050020221
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Korean Journal of Pain
1992 Volume.5 No. 2 p.221 ~ p.228
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A Comparison of the Analgesic and Side Effects of Epidural Morphine and Nalbuphine-Morphine Mixture in Post-Cesarean Section Patients
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Abstract
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The effect of epidural nalbuphine on pruritus, nausea, vomiting, voiding difficulties and/or analgesia induced by epidural morphine was determined in sixty Cesarian delivery patients. They were physical status 1 or 2 by ASA classification and
randomly
divided into three groups. They were administered morphine 3 mg only (group A), nalbuphine 5 mg with morphine 3 mg (group B), or nalbuphine 10 mg with morphine 3 mg (group C) at the time of peritoneal closure.
During postoperative 24 hours their analgesic effects were evaluated by visual analogue scale (0~10). Respiratory rates, Trieger dot test and severity of side effects (0~2) were also evaluated.
@ES The results were as follows;
@EN 1) Analgesic duration of the first epidural administration was significantly long in group A than other groups, but there was no difference between that of group B and group C.
2) Prkuritus was more severe in group A than other groups but the severity was decreased by increasing nalbuphine dosage.
3) Nausea and/or vomiting was mild in group C and the incidence of nausea nd/or vomiting compbined with pruritus was decreased by increasing nalbuphine dosage.
4) Voiding difficulties was more severe in group A than other groups but the severity was not decreased by increasing nalbuphine dosage.
5) None of the patients had objective sedation or low respiration rate (<10 times/minute).
We concluded that epidural administration of nalbuphine 10 mg with morphine 3mg for postCesarean section pain management is one of good methods to reduce side effects induced by epidural morphine.
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